The Glacial® Skin Story


Headquartered in Silicon Valley, R2 Technologies is the world leader in CryoAesthetics®  medical devices. Our Glacial® platform for precision contact cooling of the skin has been shown to reduce inflammation and also lighten dark spots.

In 2014, Pansend Life Sciences, LLC, the life sciences segment of INNOVATE (NYSE: VATE), founded R2 together with Blossom Innovations, LLC and Massachusetts General Hospital to develop a technology based on their patented method of Cryomodulation™. In 2019, R2 brought on a strategic partner, Huadong Medicine Co., Ltd.

Since that time, R2 has conducted design, development and extensive clinical research to bring Glacial® Rx, Glacial® fx and Glacial® Spa to market along with an exciting product pipeline.

Aesthetic provider performing a Glacial Rx cryotherapy facial treatment using precision cooling technology
Scientific Founders

Our scientific founders and world-famous luminaries in aesthetic medicine, focus on the development, engineering, clinical research, and commercialization of groundbreaking technologies for aesthetic providers and consumers.

Image of founder R. Rox Anderson, M.D. Glacial Rx and Glacial fx

R. Rox Anderson, M.D.

Image of founder Henry H. L. Chan, M.D., PhD Glacial Rx and Glacial fx

Henry H. L. Chan, M.D., PhD

Dieter Manstein, M.D., PhD founder of Glacial Rx and Glacial fx

Dieter Manstein, M.D., PhD

Image of founder R. Rox Anderson, M.D. Glacial Rx and Glacial fx
R. Rox Anderson, M.D.
Image of founder Henry H. L. Chan, M.D., PhD Glacial Rx and Glacial fx
Henry H. L. Chan, M.D., PhD
Dieter Manstein, M.D., PhD founder of Glacial Rx and Glacial fx
Dieter Manstein, M.D., PhD
leadership Team

Our experienced leadership team is passionate about bringing Glacial® Skin to clinics and spas worldwide so everyone can experience the benefits of healthy Glacial skin.

Tim Holt CEO of Glacial Skin by R2 Technologies
Tim Holt
President & CEO

Tim has over 20 years of experience leading, launching, and scaling aesthetic medical device companies, including Reliant, ZELTIQ, Fraxel, and CoolSculpting.

Kristine Tatsutani Chief Science & Technology Officer of Glacial Skin by R2 Technologies
Kristine Tatsutani
Chief Science & Technology Officer

Kristine has over 25-years in cryobiology research, developing cold-based medical devices, and serving as leadership for ZELTIQ.

Joanne Kells VP of Sales & Marketing for Glacial Skin by R2 Technologies
Joanne Kells
VP of Sales & Marketing

Joanne has over 17 years experience in the medical aesthetic industry, driving top sales and leading high- performing teams at Allergan, Merz, and Solta.

Angell Haiflich VP of Finance & Administration for Glacial Skin by R2 Technologies
Angell Haiflich
VP of Finance & Administration

Angell has over 20 years of experience in finance and accounting across multiple industries, including performing audits for Fortune 500 companies.
Casey Torrez VP of Operations for Glacial Skin by R2 Technologies
Casey Torrez
VP of Operations

For over 20 years, Casey has led high-performing teams in sales operations, customer service, and logistics in medical aesthetics and lifesciences.

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Board of Directors

David A. Present, MD

Chairman, Founder, and General Partner, Pansend Life Sciences, LLC

Cherine Eldumiati Plumaker

Vice Chairman, Founder, and General Partner, Pansend Life Sciences, LLC

Irina Erenburg, PhD

Founder and Chief Executive Officer, Blossom Innovations, LLC

Yuhang Zhao, PhD, MBA

Adviser to China Grand, Inc.

Seth Orlow, MD, PhD

Professor and Chair of Dermatology, NYU School of Medicine

Tim Holt, MBA

President and Chief Executive Officer, R2 Technologies, Inc.

Elaine Zhou

CEO of Sinclair China

Ken Cappell

Retired Partner PricewaterhouseCoopers LLP