The Glacial® Skin Story
Headquartered in Silicon Valley, R2 Technologies is the world leader in CryoAesthetics® medical devices. Our Glacial® platform for precision contact cooling of the skin has been shown to reduce inflammation and also lighten dark spots.
In 2014, Pansend Life Sciences, LLC, the life sciences segment of INNOVATE (NYSE: VATE), founded R2 together with Blossom Innovations, LLC and Massachusetts General Hospital to develop a technology based on their patented method of Cryomodulation™. In 2019, R2 brought on a strategic partner, Huadong Medicine Co., Ltd.
Since that time, R2 has conducted design, development and extensive clinical research to bring Glacial® Rx, Glacial® fx and Glacial® Spa to market along with an exciting product pipeline.




Our experienced leadership team is passionate about bringing Glacial® Skin to clinics and spas worldwide so everyone can experience the benefits of healthy Glacial skin.

Tim has over 20 years of experience leading, launching, and scaling aesthetic medical device companies, including Reliant, ZELTIQ, Fraxel, and CoolSculpting.

Kristine has over 25-years in cryobiology research, developing cold-based medical devices, and serving as leadership for ZELTIQ.

Joanne has over 17 years experience in the medical aesthetic industry, driving top sales and leading high- performing teams at Allergan, Merz, and Solta.

Angell has over 20 years of experience in finance and accounting across multiple industries, including performing audits for Fortune 500 companies.

For over 20 years, Casey has led high-performing teams in sales operations, customer service, and logistics in medical aesthetics and lifesciences.
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David A. Present, MD
Chairman, Founder, and General Partner, Pansend Life Sciences, LLC
Cherine Eldumiati Plumaker
Vice Chairman, Founder, and General Partner, Pansend Life Sciences, LLC
Irina Erenburg, PhD
Founder and Chief Executive Officer, Blossom Innovations, LLC
Yuhang Zhao, PhD, MBA
Adviser to China Grand, Inc.
Seth Orlow, MD, PhD
Professor and Chair of Dermatology, NYU School of Medicine
Tim Holt, MBA
President and Chief Executive Officer, R2 Technologies, Inc.
Elaine Zhou
CEO of Sinclair China
Ken Cappell
Retired Partner PricewaterhouseCoopers LLP